Antimicrobial peptide capsids of de novo design.
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ABSTRACT:
SUBMITTER: De Santis E
PROVIDER: S-EPMC5741663 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Antimicrobial peptide capsids of de novo design.
De Santis Emiliana E Alkassem Hasan H Lamarre Baptiste B Faruqui Nilofar N Bella Angelo A Noble James E JE Micale Nicola N Ray Santanu S Burns Jonathan R JR Yon Alexander R AR Hoogenboom Bart W BW Ryadnov Maxim G MG
Nature communications 20171222 1
The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches that are altogether different from antibiotics may offer promising and creative solutions. Here, we introduce a de novo peptide topology that-by emulating the virus architecture-assembles into discrete antimicrobial capsids. Using the combination of high-resolution and real-time imaging, we demonstrate that these artificial capsids assemble a ...[more]
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