Ontology highlight
ABSTRACT:
SUBMITTER: Kollmorgen G
PROVIDER: S-EPMC5741731 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Kollmorgen Gwendlyn G Palme Klara K Seidl Annette A Scheiblich Stefan S Birzele Fabian F Wilson Sabine S Clemens Christian C Voss Edgar E Kaufmann Martin M Hirzel Klaus K Rieder Natascha N Krippendorff Ben-Fillippo BF Herting Frank F Niederfellner Gerhard G
Scientific reports 20171222 1
RG7787 is a re-engineered mesothelin-targeted immunotoxin with reduced immunogenicity composed of a humanized anti-mesothelin Fab fragment and a B-cell epitope silenced 24 kD fragment of Pseudomonas exotoxin A. High prevalence of mesothelin-positive cases and a large unmet medical need make ovarian cancer a promising indication for the clinical development of RG7787. However, ovarian cancer patients also frequently have elevated serum levels of the cancer antigen 125 (CA-125). In principle this ...[more]