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Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls.

ABSTRACT: Multi-layered thin films with heterogeneous mechanical properties can be spontaneously transformed to realise various three-dimensional (3D) geometries. Here, we describe micro-patterned all-polymer films called micro-rolls that we use for encapsulating, manipulating, and observing adherent cells in vitro. The micro-rolls are formed of twin-layered films consisting of two polymers with different levels of mechanical stiffness; therefore they can be fabricated by using the strain engineering and a self-folding rolling process. By controlling the strain of the films geometrically, we can achieve 3D tubular architectures with controllable diameters. Integration with a batch release of sacrificial hydrogel layers provides a high yield and the biocompatibility of the micro-rolls with any length in the release process without cytotoxicity. Thus, the multiple cells can be wrapped in individual micro-rolls and artificially reconstructed into hollow or fibre-shaped cellular 3D constructs that possess the intrinsic morphologies and functions of living tissues. This system can potentially provide 3D bio-interfaces such as those needed for reconstruction and assembly of functional tissues and implantable tissue grafts.

SUBMITTER: Teshima TF

PROVIDER: S-EPMC5741765 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls.

Teshima Tetsuhiko F TF Nakashima Hiroshi H Ueno Yuko Y Sasaki Satoshi S Henderson Calum S CS Tsukada Shingo S

Scientific reports 20171222 1

Multi-layered thin films with heterogeneous mechanical properties can be spontaneously transformed to realise various three-dimensional (3D) geometries. Here, we describe micro-patterned all-polymer films called micro-rolls that we use for encapsulating, manipulating, and observing adherent cells in vitro. The micro-rolls are formed of twin-layered films consisting of two polymers with different levels of mechanical stiffness; therefore they can be fabricated by using the strain engineering and ...[more]

PMID: 29273722

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Project description:The worldwide COVID-19 pandemic has led to an attention on the usage of personal protective face masks. However, the longevity and safety of the commercial face masks are limited due to the charge dissipation of the electret meltblown nonwovens, which are dominate in the face mask filters. Herein, we design a type of multi-layer structured nonwovens using meltblowing and electrospinning technologies. The complex nonwovens involving meltblown and electrospun fibers are designed to possess multilevel fiber diameters and pore sizes. The micro/nanofibers with porous and wrinkled surface morphologies can well capture particulate matters (PMs), and the multilevel pore sizes contribute to low air resistance under high filtration efficiency. Airflow field simulation was carried out to understand the pressure distribution within the nonwovens in the filtration process. Meanwhile, by adding Ag nanoparticles (AgNPs) as additives, the nonwovens exhibit excellent antibacterial performance. The resultant nonwovens exhibit filtration efficiency of 99.1% for PM0.3 and low pressure drop of 105 Pa under the 10.67 cm/s inlet air velocity, and antibacterial rate of > 99.99% for Escherichia coli. These performances and functions make the designed complex nonwovens a promising filter core for face masks.Electronic supplementary materialSupplementary material (Fig. S1. The filtration efficiencies of a brand of surgical mask changes with the storage time under the condition of 100% humidity. Fig. S2. The FE-SEM images of the fibers after blocking PMs. Fig. S3. Illustration of 3D structure models of the nonwovens. Fig. S4. Diameter distribution of AgNPs. Table S1. The structure parameters and filtration performances of the PP-M fibers with and without pores and wrinkles. Table S2. Filtration performance of PP-M/PLA-M/PLA-N nonwovens and commercial face masks. Table S3. The structural parameters for the nonwovens. Table S4. The filtration efficiencies and pressure drops of the PP, PE spunbonded nonwovens, and PP-M/PLA-M/PLA-N@AgNPs nonwovens) is available in the online version of this article at 10.1007/s12274-022-4350-2.

Dataset Information

Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls.

Publications

Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls.

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