Ontology highlight
ABSTRACT:
SUBMITTER: Gangadhar TC
PROVIDER: S-EPMC5742050 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Gangadhar Tara C TC Savitch Samantha L SL Yee Stephanie S SS Xu Wei W Huang Alexander C AC Harmon Shannon S Lieberman David B DB Soucier Devon D Fan Ryan R Black Taylor A TA Morrissette Jennifer J D JJD Salathia Neeraj N Waters Jill J Zhang Shile S Toung Jonathan J van Hummelen Paul P Fan Jian-Bing JB Xu Xiaowei X Amaravadi Ravi K RK Schuchter Lynn M LM Karakousis Giorgos C GC Hwang Wei-Ting WT Carpenter Erica L EL
Pigment cell & melanoma research 20171023 1
To determine the feasibility of liquid biopsy for monitoring of patients with advanced melanoma, cell-free DNA was extracted from plasma for 25 Stage III/IV patients, most (84.0%) having received previous therapy. DNA concentrations ranged from 0.6 to 390.0 ng/ml (median = 7.8 ng/ml) and were positively correlated with tumor burden as measured by imaging (Spearman rho = 0.5435, p = .0363). Using ultra-deep sequencing for a 61-gene panel, one or more mutations were detected in 12 of 25 samples (4 ...[more]