Ontology highlight
ABSTRACT:
SUBMITTER: Puighermanal E
PROVIDER: S-EPMC5742586 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Puighermanal Emma E Biever Anne A Pascoli Vincent V Melser Su S Pratlong Marine M Cutando Laura L Rialle Stephanie S Severac Dany D Boubaker-Vitre Jihane J Meyuhas Oded O Marsicano Giovanni G Lüscher Christian C Valjent Emmanuel E
Frontiers in molecular neuroscience 20171221
The phosphorylation of the ribosomal protein S6 (rpS6) is widely used to track neuronal activity. Although it is generally assumed that rpS6 phosphorylation has a stimulatory effect on global protein synthesis in neurons, its exact biological function remains unknown. By using a phospho-deficient rpS6 knockin mouse model, we directly tested the role of phospho-rpS6 in mRNA translation, plasticity and behavior. The analysis of multiple brain areas shows for the first time that, in neurons, phosph ...[more]