Ontology highlight
ABSTRACT:
SUBMITTER: Hendrickx DAE
PROVIDER: S-EPMC5742619 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hendrickx Debbie A E DAE van Scheppingen Jackelien J van der Poel Marlijn M Bossers Koen K Schuurman Karianne G KG van Eden Corbert G CG Hol Elly M EM Hamann Jörg J Huitinga Inge I
Frontiers in immunology 20171221
In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecular mechanisms underlying lesion activity and halt, we analyzed genome-wide gene expression in rim and peri-lesional regions of chronic active and inactive MS lesions, as well as in control tissue. Gene clustering revealed patterns of gene expression s ...[more]