Ontology highlight
ABSTRACT:
SUBMITTER: Paini A
PROVIDER: S-EPMC5742636 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Paini Alicia A Sala Benito Jose Vicente JV Bessems Jos J Worth Andrew P AP
Toxicology in vitro : an international journal published in association with BIBRA 20170627 Pt 2
Physiologically based kinetic (PBK) models and the virtual cell based assay can be linked to form so called physiologically based dynamic (PBD) models. This study illustrates the development and application of a PBK model for prediction of estragole-induced DNA adduct formation and hepatotoxicity in humans. To address the hepatotoxicity, HepaRG cells were used as a surrogate for liver cells, with cell viability being used as the in vitro toxicological endpoint. Information on DNA adduct formatio ...[more]