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Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula.

ABSTRACT: This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric acid derived natural products, aconitates A-F (1-6), together with two known and ten new polybrominated phenols, symphyocladins C/D (7a/b), and symphyocladins H-Q (8a/b, 9a/b and 10-15), respectively. Structure elucidation was achieved by detailed spectroscopic (including X-ray crystallographic) analysis. We propose a plausible and convergent biosynthetic pathway involving a key quinone methide intermediate, linking aconitates and symphyocladins.

SUBMITTER: Xu X

PROVIDER: S-EPMC5742834 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula.

Xu Xiuli X Yang Haijin H Khalil Zeinab G ZG Yin Liyuan L Xiao Xue X Neupane Pratik P Bernhardt Paul V PV Salim Angela A AA Song Fuhang F Capon Robert J RJ

Marine drugs 20171201 12

This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric acid derived natural products, aconitates A-F (1-6), together with two known and ten new polybrominated phenols, symphyocladins C/D (7a/b), and symphyocladins H-Q (8a/b, 9a/b</ ...[more]

PMID: 29194381

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