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A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213.


ABSTRACT: A previously unreported dihydrochromone dimer, paecilin E (1), was isolated, together with eleven known compounds: ?-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (2), helvolic acid, secalonic acid A and fellutanine A, from the culture filtrate extract of the marine sponge-associated fungus Neosartorya fennelliae KUFA 0811. Nine previously reported metabolites, including a chromanol derivative (3), (3?, 5?, 22E), 3,5-dihydroxyergosta-7,22-dien-6-one (4), byssochlamic acid, hopan-3?,22-diol, chevalone C, sartorypyrone B, helvolic acid, lumichrome and the alkaloid harmane were isolated from the culture of the marine-sponge associated fungus Neosartorya tsunodae KUFC 9213. Paecilin E (1), dankasterone A (2), a chromanol derivative (3), (3?, 5?, 22E)-3,5-dihydroxyergosta-7,22-dien-6-one (4), hopan-3?,22-diol (5), lumichrome (6), and harmane (7) were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. While paecilin E (1) was active against S. aureus ATCC 29213 and E. faecalis ATCC 29212, dankastetrone A (2) was only effective against E. faecalis ATCC 29212 and the multidrug-resistant VRE E. faecalis A5/102. Both compounds neither inhibit biofilm mass production in any of the strains at the concentrations tested nor exhibit synergistic association with antibiotics.

SUBMITTER: Kumla D 

PROVIDER: S-EPMC5742835 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213.

Kumla Decha D   Shine Aung Tin T   Buttachon Suradet S   Dethoup Tida T   Gales Luís L   Pereira José A JA   Inácio Ângela    Costa Paulo M PM   Lee Michael M   Sekeroglu Nazim N   Silva Artur M S AMS   Pinto Madalena M M MMM   Kijjoa Anake A  

Marine drugs 20171201 12


A previously unreported dihydrochromone dimer, paecilin E (<b>1</b>), was isolated, together with eleven known compounds: β-sitostenone, ergosta-4,6,8 (14), 22-tetraen-3-one, cyathisterone, byssochlamic acid, dehydromevalonic acid lactone, chevalone B, aszonalenin, dankasterone A (<b>2</b>), helvolic acid, secalonic acid A and fellutanine A, from the culture filtrate extract of the marine sponge-associated fungus <i>Neosartorya fennelliae</i> KUFA 0811. Nine previously reported metabolites, incl  ...[more]

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