Ontology highlight
ABSTRACT:
SUBMITTER: Mancinelli R
PROVIDER: S-EPMC5742885 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Mancinelli Romina R Carpino Guido G Petrungaro Simonetta S Mammola Caterina Loredana CL Tomaipitinca Luana L Filippini Antonio A Facchiano Antonio A Ziparo Elio E Giampietri Claudia C
Oxidative medicine and cellular longevity 20171212
GSK-3 is a ubiquitously expressed serine/threonine kinase existing as GSK-3<i>α</i> and GSK-3<i>β</i> isoforms, both active under basal conditions and inactivated upon phosphorylation by different upstream kinases. Initially discovered as a regulator of glycogen synthesis, GSK-3 is also involved in several signaling pathways controlling many different key functions. Here, we discuss recent advances regarding (i) GSK-3 structure, function, regulation, and involvement in several cancers, including ...[more]