Ontology highlight
ABSTRACT:
SUBMITTER: Honda A
PROVIDER: S-EPMC5743069 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Honda Atsuko A Usui Hiroshi H Sakimura Kenji K Igarashi Michihiro M
The Journal of biological chemistry 20171031 51
RUN and FYVE domain-containing 3 (Rufy3) is an adapter protein for small GTPase proteins and is bound to activated Rap2, a Ras family protein in the developing neuron. Previously, we reported the presence of a rapid cell polarity determination mechanism involving Rufy3, which is likely required for <i>in vivo</i> neuronal development. However, the molecular details of this mechanism are unclear. To this end, here we produced Rufy3 knock-out (Rufy3-KO) mice to study the role of Rufy3 in more deta ...[more]