Ontology highlight
ABSTRACT:
SUBMITTER: Al-Ramahi I
PROVIDER: S-EPMC5743427 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Al-Ramahi Ismael I Giridharan Sai Srinivas Panapakkam SSP Chen Yu-Chi YC Patnaik Samarjit S Safren Nathaniel N Hasegawa Junya J Hasegawa Junya J de Haro Maria M Wagner Gee Amanda K AK Titus Steven A SA Jeong Hyunkyung H Clarke Jonathan J Krainc Dimitri D Zheng Wei W Irvine Robin F RF Barmada Sami S Ferrer Marc M Southall Noel N Weisman Lois S LS Botas Juan J Marugan Juan Jose JJ
eLife 20171226
The discovery of the causative gene for Huntington's disease (HD) has promoted numerous efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and potentially forestall the appearance of HD-related neurological defects. Using a cell-based model of pathogenic huntingtin expression, we identified a class of compounds that protect cells through selective inhibition of a lipid kinase, PIP4Kγ. Pharmacological inhibition or knock-down of PIP4Kγ modulates the equilib ...[more]