Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.
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ABSTRACT:
SUBMITTER: Smith LM
PROVIDER: S-EPMC5743608 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.
Smith Levi M LM Zhu Rong R Strittmatter Stephen M SM
Neuropharmacology 20171127
Alzheimer's disease remains without a disease-modifying therapy that improves symptoms after therapy withdrawal. Because no investigational agents have demonstrated disease-modifying effects clinically, we tested whether the Fyn inhibitor, saracatinib, provides persistent improvement in a transgenic model. Aged APPswe/PS1ΔE9 mice were treated with saracatinib or memantine for 4 weeks and spatial memory improved to control levels. After drug washout, there was sustained rescue of both memory func ...[more]
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