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Construction of Multifunctional Fe3O4-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy.

ABSTRACT: To accomplish effective cancer imaging and integrated therapy, the multifunctional nanotheranostic Fe3O4-MTX@HBc core-shell nanoparticles (NPs) were designed. A straightforward method was demonstrated for efficient encapsulation of magnetic NPs into the engineered virus-like particles (VLPs) through the affinity of histidine tags for the methotrexate (MTX)-Ni2+ chelate. HBc144-His VLPs shell could protect Fe3O4-MTX NPs from the recognition by the reticuloendothelial system as well as could increase their cellular uptake efficiency. Through our well-designed tactic, the photothermal efficiency of Fe3O4 NPs were obviously improved in vitro and in vivo upon near-infrared (NIR) laser irradiation. Moreover, Magnetic resonance imaging (MRI) results showed that the Fe3O4-MTX@HBc core-shell NPs were reliable T2-type MRI contrast agents for tumor imaging. Hence the Fe3O4-MTX@HBc core-shell NPs may act as a promising theranostic platform for multimodal cancer treatment.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC5743840 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Construction of Multifunctional Fe<sub>3</sub>O<sub>4</sub>-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy.

Zhang Qiang Q   Shan Wenjun W   Ai Chaochao C   Chen Zhiwei Z   Zhou Tiantian T   Lv Xiaolin X   Zhou Xi X   Ye Shefang S   Ren Lei L   Wang Xiumin X  

Nanotheranostics 20180101 1

To accomplish effective cancer imaging and integrated therapy, the multifunctional nanotheranostic Fe<sub>3</sub>O<sub>4</sub>-MTX@HBc core-shell nanoparticles (NPs) were designed. A straightforward method was demonstrated for efficient encapsulation of magnetic NPs into the engineered virus-like particles (VLPs) through the affinity of histidine tags for the methotrexate (MTX)-Ni<sup>2+</sup> chelate. HBc<sub>144</sub>-His VLPs shell could protect Fe<sub>3</sub>O<sub>4</sub>-MTX NPs from the re  ...[more]

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