Ontology highlight
ABSTRACT:
SUBMITTER: Serra S
PROVIDER: S-EPMC5744057 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Serra Sara S Vaisitti Tiziana T Audrito Valentina V Bologna Cinzia C Buonincontri Roberta R Chen Shih-Shih SS Arruga Francesca F Brusa Davide D Coscia Marta M Jaksic Ozren O Inghirami Giorgio G Rossi Davide D Furman Richard R RR Robson Simon C SC Gaidano Gianluca G Chiorazzi Nicholas N Deaglio Silvia S
Blood advances 20161122 1
The chronic lymphocytic leukemia (CLL) niche is a closed environment where leukemic cells derive growth and survival signals through their interaction with macrophages and T lymphocytes. Here, we show that the CLL lymph node niche is characterized by overexpression and activation of HIF-1α, which increases adenosine generation and signaling, affecting tumor and host cellular responses. Hypoxia in CLL lymphocytes modifies central metabolic pathways, protects against drug-driven apoptosis, and ind ...[more]