Ontology highlight
ABSTRACT:
SUBMITTER: Clegg LE
PROVIDER: S-EPMC5744173 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Clegg Lindsay E LE Ganta Vijay C VC Annex Brian H BH Mac Gabhann Feilim F
CPT: pharmacometrics & systems pharmacology 20171128 12
We built a whole-body computational model to study the role of the poorly understood vascular endothelial growth factor (VEGF)<sub>165b</sub> splice isoform in peripheral artery disease (PAD). This model was built and validated using published and new experimental data from cells, mice, and humans, and explicitly accounts for known properties of VEGF<sub>165b</sub> : lack of extracellular matrix (ECM)-binding and weak phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR2) in v ...[more]