Dataset Information

Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

Coarse particulate matter (P_10-2.5) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM_10-2.5 is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM_10-2.5 remain unknown.

Objectives

To quantify cross-sectional associations between RV dysfunction and PM_10-2.5 mass and components among older adults and susceptible populations.

Methods

We used baseline cardiac magnetic resonance images from 1,490 participants (45-84 y old) from the Multi-Ethnic Study of Atherosclerosis and assigned 5-y residential concentrations of PM_10-2.5 mass, copper, zinc, phosphorus, silicon, and endotoxin, using land-use regression models. We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants using linear regression. We further examined personal susceptibility.

Results

We found positive associations of RV mass and, to a lesser extent, end diastolic volume with PM_10-2.5 mass among susceptible populations including smokers and persons with emphysema. After adjustment for copollutants, an interquartile range increase in PM_10-2.5 mass (2.2??g/m³) was associated with 0.5 g (95% CI: 0.0, 1.0), 0.9 g (95% CI: 0.1, 1.7), and 1.4 g (95% CI: 0.4, 2.5) larger RV mass among former smokers, current smokers, and persons with emphysema, respectively. No associations were found with healthy individuals or with ejection fraction.

Conclusions

Alterations to RV structure may represent a mechanism by which long-term PM_10-2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. https://doi.org/10.1289/EHP658.

SUBMITTER: D'Souza JC

PROVIDER: S-EPMC5744657 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.

D'Souza Jennifer C JC Kawut Steven M SM Elkayam Laura R LR Sheppard Lianne L Thorne Peter S PS Jacobs David R DR Bluemke David A DA Lima Joao A C JAC Kaufman Joel D JD Larson Timothy V TV Adar Sara D SD

Environmental health perspectives 20170727 7

<h4>Background</h4>Coarse particulate matter (P<sub>10-2.5</sub>) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM<sub>10-2.5</sub> is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM<sub>10-2.5</sub> remain unknown.<h4>Objectives</h4>To quantify cross-sectional associations between R ...[more]

PMID: 28760719

Similar Datasets

Project description:BackgroundParticulate matter (PM) exposure may directly affect the pulmonary vasculature. Although the pulmonary vasculature is not easily measurable, differential associations for right ventricular (RV) and left ventricular (LV) mass may provide an indirect assessment of pulmonary vascular damage.ObjectivesWe tested whether long-term exposure to PM < 2.5 ?m (PM2.5) is associated with greater RV mass and RV mass/end-diastolic volume ratio relative to the LV.MethodsThe Multi-Ethnic Study of Atherosclerosis performed cardiac magnetic resonance (CMR) imaging among participants 45-84 years old without clinical cardiovascular disease in 2000-2002 in six U.S. cities. A fine-scale spatiotemporal model estimated ambient PM2.5 exposure in the year before CMR; individually weighted estimates accounted for indoor exposure to ambient PM2.5. Linear regression models were adjusted for demographics, anthropometrics, smoking status, cardiac risk factors, and LV parameters, with additional adjustment for city.ResultsThe 4,041 included participants had a mean age of 61.5 years, and 47% were never smokers. The mean ambient PM2.5 was 16.4 ?g/m3 and individually weighted PM2.5 was 11.0 ?g/m3. PM2.5 exposure was associated with greater RV mass [ambient: 0.11 g per 5 ?g/m3 (95% CI: -0.05, 0.27); individually weighted: 0.20 g per 5 ?g/m3 (95% CI: 0.04, 0.36)] and a greater RV mass/end-diastolic volume ratio conditional on LV parameters. City-adjusted results for RV mass were of greater magnitude and were statistically significant for both measures of PM2.5, whereas those for RV mass/end-diastolic volume ratio were attenuated.ConclusionsLong-term PM2.5 exposures were associated with greater RV mass and RV mass/end-diastolic volume ratio conditional on the LV; however, additional adjustment for city attenuated the RV mass/end-diastolic volume findings. These findings suggest that PM2.5 exposure may be associated with subclinical cardiopulmonary differences in this general population sample.CitationAaron CP, Chervona Y, Kawut SM, Diez Roux AV, Shen M, Bluemke DA, Van Hee VC, Kaufman JD, Barr RG. 2016. Particulate matter exposure and cardiopulmonary differences in the Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect 124:1166-1173;?http://dx.doi.org/10.1289/ehp.1409451.

Dataset Information

Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.

Background

Objectives

Methods

Results

Conclusions

Publications

Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.

Similar Datasets

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