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ABSTRACT: Background
Coarse particulate matter (P10-2.5) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM10-2.5 is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM10-2.5 remain unknown.Objectives
To quantify cross-sectional associations between RV dysfunction and PM10-2.5 mass and components among older adults and susceptible populations.Methods
We used baseline cardiac magnetic resonance images from 1,490 participants (45-84 y old) from the Multi-Ethnic Study of Atherosclerosis and assigned 5-y residential concentrations of PM10-2.5 mass, copper, zinc, phosphorus, silicon, and endotoxin, using land-use regression models. We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants using linear regression. We further examined personal susceptibility.Results
We found positive associations of RV mass and, to a lesser extent, end diastolic volume with PM10-2.5 mass among susceptible populations including smokers and persons with emphysema. After adjustment for copollutants, an interquartile range increase in PM10-2.5 mass (2.2??g/m3) was associated with 0.5 g (95% CI: 0.0, 1.0), 0.9 g (95% CI: 0.1, 1.7), and 1.4 g (95% CI: 0.4, 2.5) larger RV mass among former smokers, current smokers, and persons with emphysema, respectively. No associations were found with healthy individuals or with ejection fraction.Conclusions
Alterations to RV structure may represent a mechanism by which long-term PM10-2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. https://doi.org/10.1289/EHP658.
SUBMITTER: D'Souza JC
PROVIDER: S-EPMC5744657 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
D'Souza Jennifer C JC Kawut Steven M SM Elkayam Laura R LR Sheppard Lianne L Thorne Peter S PS Jacobs David R DR Bluemke David A DA Lima Joao A C JAC Kaufman Joel D JD Larson Timothy V TV Adar Sara D SD
Environmental health perspectives 20170727 7
<h4>Background</h4>Coarse particulate matter (P<sub>10-2.5</sub>) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM<sub>10-2.5</sub> is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM<sub>10-2.5</sub> remain unknown.<h4>Objectives</h4>To quantify cross-sectional associations between R ...[more]