Ontology highlight
ABSTRACT:
SUBMITTER: Pelliccia JL
PROVIDER: S-EPMC5745080 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
eLife 20171115
Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; <i>southpaw</i> directs left-right asymmetries, while <i>squint</i> and <i>cyclops</i> function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has not been fully explored. We show that zygotic expression of <i>gdf3</i> is dispensable for embryon ...[more]