Ontology highlight
ABSTRACT:
SUBMITTER: Anderson C
PROVIDER: S-EPMC5745083 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Anderson Caitlin C Reiss India I Zhou Cyrus C Cho Annie A Siddiqi Haziq H Mormann Benjamin B Avelis Cameron M CM Deford Peter P Bergland Alan A Roberts Elijah E Taylor James J Vasiliauskas Daniel D Johnston Robert J RJ
eLife 20171218
Each individual perceives the world in a unique way, but little is known about the genetic basis of variation in sensory perception. In the fly eye, the random mosaic of color-detecting R7 photoreceptor subtypes is determined by stochastic on/off expression of the transcription factor Spineless (Ss). In a genome-wide association study, we identified a naturally occurring insertion in a regulatory DNA element in <i>ss</i> that lowers the ratio of Ss<sup>ON</sup> to Ss<sup>OFF</sup> cells. This ch ...[more]