Unknown

Dataset Information

0

Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.


ABSTRACT: The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis, and five differentially expressed in chronic epilepsy. Of these, 13 were not identified in any of the individual studies. To assess the role of these miRNAs, we predicted their mRNA targets and then filtered the list to include only target genes expressed in DG and negatively correlated with miRNA expression. Functional enrichment analysis of mRNA targets of miRNAs dysregulated during epileptogenesis suggested a role for molecular processes related to inflammation and synaptic function. Our results identify new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta-analysis in maximizing value from preclinical data.

SUBMITTER: Srivastava PK 

PROVIDER: S-EPMC5745610 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.

Srivastava Prashant K PK   Roncon Paolo P   Lukasiuk Katarzyna K   Gorter Jan A JA   Aronica Eleonora E   Pitkänen Asla A   Petretto Enrico E   Johnson Michael R MR   Simonato Michele M  

eNeuro 20171101 6


The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis,  ...[more]

Similar Datasets

| S-EPMC7868380 | biostudies-literature
2021-01-18 | PXD023048 | Pride
| S-EPMC3153561 | biostudies-literature
| S-EPMC4282449 | biostudies-literature
| S-EPMC9177400 | biostudies-literature
| S-EPMC3142893 | biostudies-literature
| S-EPMC5423390 | biostudies-literature
| S-EPMC5342204 | biostudies-literature
| S-EPMC5546763 | biostudies-literature
| S-EPMC2829853 | biostudies-literature