Ontology highlight
ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC5746509 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kim Mina M Lee Hae-Ahm HA Cho Hyun-Min HM Kang Seol-Hee SH Lee Eunjo E Kim In Kyeom IK
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20171222 1
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors (HDACi) could attenuate hepatic steatosis through glucocorticoid receptor (GR) acetylation in experimental CS. To induce CS, we administered adrenocorticotropic hormone (ACTH; 40 ng/kg/day) to Sprague-Dawley rats by subcutaneous infusion with osmotic mini-pumps. We ...[more]