Ontology highlight
ABSTRACT:
SUBMITTER: Van Opdenbosch N
PROVIDER: S-EPMC5746600 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Van Opdenbosch Nina N Van Gorp Hanne H Verdonckt Maarten M Saavedra Pedro H V PHV de Vasconcelos Nathalia M NM Gonçalves Amanda A Vande Walle Lieselotte L Demon Dieter D Matusiak Magdalena M Van Hauwermeiren Filip F D'Hont Jinke J Hochepied Tino T Krautwald Stefan S Kanneganti Thirumala-Devi TD Lamkanfi Mohamed M
Cell reports 20171201 12
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC. Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediated apoptosis as an alternative cell death program in caspase-1<sup>-/-</sup> macrophages and intestinal epithelial organoids (IECs). The caspase-8 adaptor FADD was recruited to ASC specks, which served as cytosolic platforms for caspase-8 activation and NLRP1b ...[more]