Ontology highlight
ABSTRACT:
SUBMITTER: Hwang S
PROVIDER: S-EPMC5747309 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Hwang Sunyoung S Gustafsson H Tobias HT O'Sullivan Ciara C Bisceglia Gianna G Huang Xinhe X Klose Christian C Schevchenko Andrej A Dickson Robert C RC Cavaliere Paola P Dephoure Noah N Torres Eduardo M EM
Cell reports 20171201 13
Aneuploidy disrupts cellular homeostasis. However, the molecular mechanisms underlying the physiological responses and adaptation to aneuploidy are not well understood. Deciphering these mechanisms is important because aneuploidy is associated with diseases, including intellectual disability and cancer. Although tumors and mammalian aneuploid cells, including several cancer cell lines, show altered levels of sphingolipids, the role of sphingolipids in aneuploidy remains unknown. Here, we show th ...[more]