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NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells.

ABSTRACT: It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that NOS1AP variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if NOS1AP variation is associated with impaired wound healing and with SPC mobilization in those with DFU. In longitudinal cohort study we demonstrate that NOS1AP variants rs16849113 and rs19649113 are associated with impaired wound healing and with SPC mobilization in those with DFU. We believe that further study of NOS1AP is merited and that it NOS1AP might be associated with a functional impairment.

SUBMITTER: Margolis DJ 

PROVIDER: S-EPMC5747323 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells.

Margolis David J DJ   Hampton Michelle M   Hoffstad Ole O   Mala D Scot DS   Mirza Ziad Z   Woltereck Diana D   Shannon Steven S   Troiano Michael A MA   Mitra Nandita N   Yang Ming M   Bhopale Veena M VM   Thom Stephen R SR  

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20170814 4

It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that NOS1AP variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if NOS1AP variation is associated with impaired wound healing and with SPC  ...[more]