Ontology highlight
ABSTRACT:
SUBMITTER: Hayasaka N
PROVIDER: S-EPMC5747517 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Hayasaka Naoto N Hirano Arisa A Miyoshi Yuka Y Tokuda Isao T IT Yoshitane Hikari H Matsuda Junichiro J Fukada Yoshitaka Y
eLife 20171211
Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in <i>Sik3</i>-deficient mice (<i>Sik3<sup>-/-</sup></i>), we observed that circadian rhythmicity of the metabolisms was phase-delayed. <i>Sik3<sup>-/-</sup></i> mice also exhibited other circadian abnormalities, including lengthening of the period, impaired entrainment to the light-dark cycle, phase variation in locomotor activities, and aberrant physiological r ...[more]