Ontology highlight
ABSTRACT:
SUBMITTER: Dong TX
PROVIDER: S-EPMC5747518 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
eLife 20171214
Ca<sup>2+</sup> influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing the frequency of pauses in human T cells migrating through confined spaces, even in the absence of extrinsic cell contacts or antigen recognition. Utilizing a novel ratiometric genetically encoded cytosolic Ca<sup>2+</sup> indicator, Sals ...[more]