Ontology highlight
ABSTRACT:
SUBMITTER: Smith AR
PROVIDER: S-EPMC5747529 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Smith Adam R AR Smith Rebecca G RG Condliffe Daniel D Hannon Eilis E Schalkwyk Leonard L Mill Jonathan J Lunnon Katie K
Neurobiology of aging 20160716
Although mutations within the TREM2 gene have been robustly associated with Alzheimer's disease, it is not known whether alterations in the regulation of this gene are also involved in pathogenesis. Here, we present data demonstrating increased DNA methylation in the superior temporal gyrus in Alzheimer's disease brain at a CpG site located 289 bp upstream of the transcription start site of the TREM2 gene in 3 independent study cohorts using 2 different technologies (Illumina Infinium 450K methy ...[more]