Ontology highlight
ABSTRACT:
SUBMITTER: Ardura-Fabregat A
PROVIDER: S-EPMC5747579 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ardura-Fabregat A A Boddeke E W G M EWGM Boza-Serrano A A Brioschi S S Castro-Gomez S S Ceyzériat K K Dansokho C C Dierkes T T Gelders G G Heneka Michael T MT Hoeijmakers L L Hoffmann A A Iaccarino L L Jahnert S S Kuhbandner K K Landreth G G Lonnemann N N Löschmann P A PA McManus R M RM Paulus A A Reemst K K Sanchez-Caro J M JM Tiberi A A Van der Perren A A Vautheny A A Venegas C C Webers A A Weydt P P Wijasa T S TS Xiang X X Yang Y Y
CNS drugs 20171201 12
Over the past few decades, research on Alzheimer's disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by findings from genetic, pre-clinical, and clinical studies. Various proteins that arise during neurodegenera ...[more]