Ontology highlight
ABSTRACT:
SUBMITTER: Su Y
PROVIDER: S-EPMC5748184 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20171211 52
Continuous BRAF inhibition of <i>BRAF</i> mutant melanomas triggers a series of cell state changes that lead to therapy resistance and escape from immune control before establishing acquired resistance genetically. We used genome-wide transcriptomics and single-cell phenotyping to explore the response kinetics to BRAF inhibition for a panel of patient-derived <i>BRAF</i><sup><i>V600</i></sup> -mutant melanoma cell lines. A subset of plastic cell lines, which followed a trajectory covering multip ...[more]