Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.

ABSTRACT: Cell-surface carbohydrates play important roles in numerous biological processes through their interactions with various protein-binding partners. These interactions are made possible by the vast structural diversity of carbohydrates and the diverse array of carbohydrate presentations on the cell surface. Among the most complex and important carbohydrates are glycosaminoglycans (GAGs), which display varied stereochemistry, chain lengths, and patterns of sulfation. GAG-protein interactions participate in neuronal development, angiogenesis, spinal cord injury, viral invasion, and immune response. Unfortunately, little structural information is available for these complexes; indeed, for the highly sulfated chondroitin sulfate motifs, CS-E and CS-D, there are no structural data. We describe he

SUBMITTER: Griffith AR 

PROVIDER: S-EPMC5748211 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature