Pharmacogenomics Guided-Personalization of Warfarin and Tamoxifen.
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ABSTRACT:
SUBMITTER: Wigle TJ
PROVIDER: S-EPMC5748632 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Pharmacogenomics Guided-Personalization of Warfarin and Tamoxifen.
Wigle Theodore J TJ Jansen Laura E LE Teft Wendy A WA Kim Richard B RB
Journal of personalized medicine 20171213 4
The use of pharmacogenomics to personalize drug therapy has been a long-sought goal for warfarin and tamoxifen. However, conflicting evidence has created reason for hesitation in recommending pharmacogenomics-guided care for both drugs. This review will provide a summary of the evidence to date on the association between cytochrome P450 enzymes and the clinical end points of warfarin and tamoxifen therapy. Further, highlighting the clinical experiences that we have gained over the past ten years ...[more]
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