Shared cancer neoantigens: Making private matters public.
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ABSTRACT:
SUBMITTER: Klebanoff CA
PROVIDER: S-EPMC5748868 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Shared cancer neoantigens: Making private matters public.
Klebanoff Christopher A CA Wolchok Jedd D JD
The Journal of experimental medicine 20171221 1
In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a "public" neoantigen. ...[more]
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