Major Developments in the Design of Inhibitors along the Kynurenine Pathway.
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ABSTRACT:
SUBMITTER: Jacobs KR
PROVIDER: S-EPMC5748880 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Major Developments in the Design of Inhibitors along the Kynurenine Pathway.
Jacobs Kelly R KR Castellano-Gonzalez Gloria G Guillemin Gilles J GJ Lovejoy David B DB
Current medicinal chemistry 20170101 23
Disrupted kynurenine pathway (KP) metabolism has been implicated in the progression of neurodegenerative disease, psychiatric disorders and cancer. Modulation of enzyme activity along this pathway may therefore offer potential new therapeutic strategies for these conditions. Considering their prominent positions in the KP, the enzymes indoleamine 2,3-dioxygenase, kynurenine 3-monooxygenase and kynurenine aminotransferase, appear the most attractive targets. Already, increasing interest in this p ...[more]
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