Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesan AM
PROVIDER: S-EPMC5749509 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Venkatesan Arvind M AM Vyas Rajesh R Gramann Alec K AK Dresser Karen K Gujja Sharvari S Bhatnagar Sanchita S Chhangawala Sagar S Gomes Camilla Borges Ferreira CBF Xi Hualin Simon HS Lian Christine G CG Houvras Yariv Y Edwards Yvonne J K YJK Deng April A Green Michael M Ceol Craig J CJ
The Journal of clinical investigation 20171204 1
Oncogenomic studies indicate that copy number variation (CNV) alters genes involved in tumor progression; however, identification of specific driver genes affected by CNV has been difficult, as these rearrangements are often contained in large chromosomal intervals among several bystander genes. Here, we addressed this problem and identified a CNV-targeted oncogene by performing comparative oncogenomics of human and zebrafish melanomas. We determined that the gene encoding growth differentiation ...[more]