Ontology highlight
ABSTRACT:
SUBMITTER: Maurer S
PROVIDER: S-EPMC5749664 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Oncoimmunology 20171127 2
Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D ligands, in particular MICA and MICB, on tumor cells, which was mirrored by enhanced release of their soluble ectodomains. Similar results were obtained upon exposure of tumor cells to platelet-releasat ...[more]