Ontology highlight
ABSTRACT:
SUBMITTER: Kroigard AB
PROVIDER: S-EPMC5749725 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Krøigård Anne Bruun AB Larsen Martin Jakob MJ Lænkholm Anne-Vibeke AV Knoop Ann S AS Jensen Jeanette Dupont JD Bak Martin M Mollenhauer Jan J Thomassen Mads M Kruse Torben A TA
PloS one 20180102 1
Cancer results from alterations at essential genomic sites and is characterized by uncontrolled cell proliferation, invasion and metastasis. Identification of driver genes of metastatic progression is essential, as metastases, not primary tumors, are fatal. To gain insight into the mutational concordance between different steps of malignant progression we performed exome sequencing and validation with targeted deep sequencing of successive steps of malignant progression from pre-invasive stages ...[more]