Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept.

ABSTRACT:

Objective

We investigated the capacity of microRNAs isolated from peripheral blood buffy coat collected late during the first trimester to predict preeclampsia.

Study design

The cohort study comprised 48 pregnant women with the following pregnancy outcomes: 8 preeclampsia and 40 with normal delivery outcomes. Quantitative rtPCR was performed on a panel of 30 microRNAs from buffy coat samples drawn at a mean of 12.7±0.5 weeks gestation. MicroRNA Risk Scores were calculated and AUC-ROC calculations derived.

Results

The AUC-ROC for preeclampsia risk was 0.91 (p<0.0001). When women with normal delivery and high-risk background (those with SLE/APS, chronic hypertension and/or Type 2 Diabetes) were compared to women who developed preeclampsia but with a normal risk backgrou

SUBMITTER: Winger EE 

PROVIDER: S-EPMC5749845 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature