Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.
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ABSTRACT:
SUBMITTER: Noh K
PROVIDER: S-EPMC5749980 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.
Noh Kyunghee K Mangala Lingegowda S LS Han Hee-Dong HD Zhang Ningyan N Pradeep Sunila S Wu Sherry Y SY Ma Shaolin S Mora Edna E Rupaimoole Rajesha R Jiang Dahai D Wen Yunfei Y Shahzad Mian M K MMK Lyons Yasmin Y Cho MinSoon M Hu Wei W Nagaraja Archana S AS Haemmerle Monika M Mak Celia S L CSL Chen Xiuhui X Gharpure Kshipra M KM Deng Hui H Xiong Wei W Kingsley Charles V CV Liu Jinsong J Jennings Nicholas N Birrer Michael J MJ Bouchard Richard R RR Lopez-Berestein Gabriel G Coleman Robert L RL An Zhiqiang Z Sood Anil K AK
Cell reports 20171201 10
Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we show significantly increased EGFL6 expression in tumor versus wound or normal endothelial cells. Using a series of in vitro and in vivo studies with orthotopic and genetically engineered mouse models, we demonstrate the mechanisms by which EGFL6 st ...[more]
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