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Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety.


ABSTRACT: Two series of novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety were prepared as insecticidal agents against the oriental armyworm, Mythimna separata Walker. The structural assignment was based on the spectroscopic and X-ray analysis data. Among all the target compounds, compounds 4b, 4k, 5b, 5j and 5k exhibited more potent insecticidal activity with final mortality rates (FMRs) of more than 65%, especially 4k with the FMR of 75.9%, when compared with toosendanin. Some interesting results of structure-activity relationships are also discussed.

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5750010 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety.

Guo Yong Y   Wang Xiaoguang X   Fan Jiangping J   Zhang Qian Q   Wang Yi Y   Zhao Yi Y   Huang Mengxing M   Ding Ming M   Zhang Yanbing Y  

Royal Society open science 20171213 12


Two series of novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety were prepared as insecticidal agents against the oriental armyworm, <i>Mythimna separata</i> Walker. The structural assignment was based on the spectroscopic and X-ray analysis data. Among all the target compounds, compounds <b>4b</b>, <b>4k</b>, <b>5b</b>, <b>5j</b> and <b>5k</b> exhibited more potent insecticidal activity with final mortality rates (FMRs) of more than 65%, especially <b>4k</b> with the FMR of  ...[more]

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