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Manganese molybdate nanoflakes on silicon microchannel plates as novel nano energetic material.

ABSTRACT: Nano energetic materials have attracted great attention recently owing to their potential applications for both civilian and military purposes. By introducing silicon microchannel plates (Si-MCPs) three-dimensional (3D)-ordered structures, monocrystalline MnMoO₄ with a size of tens of micrometres and polycrystalline MnMoO₄ nanoflakes are produced on the surface and sidewall of nickel-coated Si-MCP, respectively. The MnMoO₄ crystals ripen controllably forming polycrystalline nanoflakes with lattice fringes of 0.542?nm corresponding to the [Formula: see text] plane on the sidewall. And these MnMoO₄ nanoflakes show apparent thermite performance which is rarely reported and represents MnMoO₄ becoming a new category of energetic materials after nanocrystallization. Additionally, the nanocrystallization mechanism is interpreted by ionic diffusion caused by 3D structure. The results indicate that the Si-MCP is a promising substrate for nanocrystallization of energetic materials such as MnMoO₄.

SUBMITTER: Zhang C

PROVIDER: S-EPMC5750022 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Manganese molybdate nanoflakes on silicon microchannel plates as novel nano energetic material.

Zhang Chi C Wu Dajun D Shi Liming L Zhu Yiping Y Xiong Dayuan D Xu Shaohui S Huang Rong R Qi Ruijuan R Zhang Wenchao W Wang Lianwei L Chu Paul K PK

Royal Society open science 20171206 12

Nano energetic materials have attracted great attention recently owing to their potential applications for both civilian and military purposes. By introducing silicon microchannel plates (Si-MCPs) three-dimensional (3D)-ordered structures, monocrystalline MnMoO4 with a size of tens of micrometres and polycrystalline MnMoO4 nanoflakes are produced on the surface and sidewall of nickel-coated Si-MCP, respectively. The MnMoO4 crystals ripen controllably forming poly ...[more]

PMID: 29308255

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Project description:Certain types of cationic metal ions, such as Mn2+ are able to activate immune functions via the stimulator of interferon genes (STING) pathway, showing potential applications in eliciting antitumor immunity. How anionic ions interact with immune cells remains largely unknown. Herein, selecting from a range of cationic and anionic ions, we were excited to discover that MoO42− could act as a cGAS-STING agonist and further confirmed the capability of Mn2+ to activate the cGAS-STING pathway. Inspired by such findings, we synthesized manganese molybdate nanoparticles with polyethylene glycol modification (MMP NDs) for cancer metalloimmunotherapy. Meanwhile, MMP NDs could consume glutathione (GSH) over-expressed in tumors and induce ferroptosis owing to high-valence Mo and Mn to elicit tumor-specific immune responses, which was further amplified by MMP-triggered the cGAS-STING activation. In turn, activated CD8+ T cells to secrete high levels of interferon γ (IFN-γ) and reduced GPX4 expression in tumor cells to trigger ferroptosis-specific lipid peroxidation, which constituted a “cycle” of therapy. As a result, the metalloimmunotherapy with systemic administration of MMP NDs offered a remarkable tumor inhibition effect for a variety of tumor models. Our work for the first time discovered the ability of anionic metal ions to activate the immune system and rationally designed bimetallic oxide nanostructures as a multifunctional therapeutic nanoplatform for tumor immunotherapy. Graphical abstract Metal cations and anions with the strongest cGAS-STING activation were screened using 293-Dual™ mSTING cells and then employed to construct bimetallic oxide MMO NDs, which were then modified with DSPE-PEG to obtain MMP NDs. MMP NDs containing Mn2+ and MoO42− showed effective cGAS-STING activation. After either local or systemic administration, MMP NDs could consume the highly expressed GSH in tumor cells, break the redox balance, inhibit the activity of the GPX4 enzyme, and subsequently lead to ferroptosis of tumor cells. Tumor debris in the presence of MMP NDs would then trigger tumor-specific cell immunity.Image 1 Highlights • A variety of metal cations and anions were screened and discovered that Mn2+ and MoO42− had the most potent ability to activate the cGAS-STING pathway.• Bimetallic oxide manganese molybdate nanoparticles (MMP NPs) were constructed for amplifying cGAS-STING activation and inducing ferroptosis.• The activated CD8+ T cells secreted high levels of interferon γ (IFN-γ) and reduced GPX4 expression in tumor cells to constitute a “cycle” of therapy.• MMP NPs were able to reverse the immunosuppressive tumor microenvironment and simultaneously realize the dual functions of initiating and enhancing CIT.• Our work used ion screening as the basis for the construction of bimetallic oxides as a cancer immunotherapy nanomedicine platform.

Dataset Information

Manganese molybdate nanoflakes on silicon microchannel plates as novel nano energetic material.

Publications

Manganese molybdate nanoflakes on silicon microchannel plates as novel nano energetic material.

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