Ontology highlight
ABSTRACT:
SUBMITTER: Bluemn EG
PROVIDER: S-EPMC5750052 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20171001 4
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highly effective, AR antagonism can produce tumors that bypass a functional requirement for AR, often through neuroendocrine (NE) transdifferentiation. Through the molecular assessment of mPCs over two decades, we find a phenotypic shift has occurred in mPC with the emergence of an AR-null NE-null phenotype. These " ...[more]