Ontology highlight
ABSTRACT:
SUBMITTER: Valderrama JA
PROVIDER: S-EPMC5750061 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Valderrama J Andrés JA Riestra Angelica M AM Gao Nina J NJ LaRock Christopher N CN Gupta Naveen N Ali Syed Raza SR Hoffman Hal M HM Ghosh Partho P Nizet Victor V
Nature microbiology 20170807 10
Group A Streptococcus (GAS) is among the top ten causes of infection-related mortality in humans. M protein is the most abundant GAS surface protein, and M1 serotype GAS strains are associated with invasive infections, including necrotizing fasciitis and toxic shock syndrome. Here, we report that released, soluble M1 protein triggers programmed cell death in macrophages (Mϕ). M1 served as a second signal for caspase-1-dependent NLRP3 inflammasome activation, inducing maturation and release of pr ...[more]