Ontology highlight
ABSTRACT:
SUBMITTER: Han S
PROVIDER: S-EPMC5750221 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180102 1
In human mutant BRAF melanoma cells, the stemness transcription factor FOXD3 is rapidly induced by inhibition of ERK1/2 signaling and mediates adaptive resistance to RAF inhibitors. However, the mechanism underlying ERK signaling control of FOXD3 expression remains unknown. Here we show that SOX10 is both necessary and sufficient for RAF inhibitor-induced expression of FOXD3 in mutant BRAF melanoma cells. SOX10 activates the transcription of FOXD3 by binding to a regulatory element in FOXD3 prom ...[more]