Ontology highlight
ABSTRACT:
SUBMITTER: Linde N
PROVIDER: S-EPMC5750231 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Linde Nina N Casanova-Acebes Maria M Sosa Maria Soledad MS Mortha Arthur A Rahman Adeeb A Farias Eduardo E Harper Kathryn K Tardio Ethan E Reyes Torres Ivan I Jones Joan J Condeelis John J Merad Miriam M Aguirre-Ghiso Julio A JA
Nature communications 20180102 1
Cancer cell dissemination during very early stages of breast cancer proceeds through poorly understood mechanisms. Here we show, in a mouse model of HER2<sup>+</sup> breast cancer, that a previously described sub-population of early-evolved cancer cells requires macrophages for early dissemination. Depletion of macrophages specifically during pre-malignant stages reduces early dissemination and also results in reduced metastatic burden at end stages of cancer progression. Mechanistically, we sho ...[more]