¹⁸F-FDG Uptake During Early Adjuvant Chemotherapy Predicts Histologic Response in Pediatric and Young Adult Patients with Osteosarcoma.

ABSTRACT: The purpose of this study was to determine the relationship of ¹⁸F-FDG uptake in the primary tumor at diagnosis, during therapy, and after therapy with a histologic response and event-free survival in pediatric and young adult patients with osteosarcoma (OS). Methods: Serial (baseline and 5 and 10 wk after start of therapy) ¹⁸F-FDG PET/CT imaging was performed in patients with newly diagnosed OS treated uniformly in a therapeutic trial at a single institution. Whole-body images were obtained approximately 1 h after injection of ¹⁸F-FDG. Logistic regression was used to study the association of tumor uptake and changes in SUV_max between 0, 5, and 10 wk for both clinical endpoints. Results: Thirty-four patients (17 males; median age, 1

SUBMITTER: Davis JC 

PROVIDER: S-EPMC5750521 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature