Influenza A Virus M2 Protein: Roles from Ingress to Egress.
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ABSTRACT:
SUBMITTER: Manzoor R
PROVIDER: S-EPMC5751251 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Influenza A Virus M2 Protein: Roles from Ingress to Egress.
Manzoor Rashid R Igarashi Manabu M Takada Ayato A
International journal of molecular sciences 20171207 12
Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest <i>bona fide</i>, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeostasis in a variety of ways. It is also the target for ion channel inhibitors, i.e., anti-influenza drugs. Thus far, several studies have been conducted to elucidate its biophysical characteristics, structure-function relationships of the ion ...[more]
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