Ontology highlight
ABSTRACT:
SUBMITTER: Wonderlich ER
PROVIDER: S-EPMC5751439 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Wonderlich Elizabeth R ER Swan Zachary D ZD Bissel Stephanie J SJ Hartman Amy L AL Carney Jonathan P JP O'Malley Katherine J KJ Obadan Adebimpe O AO Santos Jefferson J Walker Reagan R Sturgeon Timothy J TJ Frye Lonnie J LJ Maiello Pauline P Scanga Charles A CA Bowling Jennifer D JD Bouwer Anthea L AL Duangkhae Parichat A PA Wiley Clayton A CA Flynn JoAnne L JL Wang Jieru J Cole Kelly S KS Perez Daniel R DR Reed Douglas S DS Barratt-Boyes Simon M SM
Journal of immunology (Baltimore, Md. : 1950) 20170106 4
Human infections with highly pathogenic avian influenza A (H5N1) virus are frequently fatal but the mechanisms of disease remain ill-defined. H5N1 infection is associated with intense production of proinflammatory cytokines, but whether this cytokine storm is the main cause of fatality or is a consequence of extensive virus replication that itself drives disease remains controversial. Conventional intratracheal inoculation of a liquid suspension of H5N1 influenza virus in nonhuman primates likel ...[more]