Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC5751546 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yu Jiayi J Wu Xiaowen X Yan Junya J Yu Huan H Xu Longwen L Chi Zhihong Z Sheng Xinan X Si Lu L Cui Chuanliang C Dai Jie J Ma Meng M Xu Tianxiao T Kong Yan Y Guo Jun J
Journal of hematology & oncology 20180103 1
<h4>Background</h4>Chimeric antigen receptor (CAR)-engineered T cells have demonstrated promising clinical efficacy in patients with B cell lymphoma. However, the application of CAR-T cell therapy in the treatment of other solid tumors has been limited. We incorporated 4-1BB into the anti-GD2 CAR-T cells to test their cytotoxicity in melanoma in vitro and in vivo. Moreover, we reported the expression of ganglioside GD2 in non-Caucasian melanoma populations for the first time, thus providing a ba ...[more]