Dataset Information

Opium use and risk of mortality from digestive diseases: a prospective cohort study.

ABSTRACT: OBJECTIVES:Opium use, particularly in low doses, is a common practice among adults in northeastern Iran. We aimed to investigate the association between opium use and subsequent mortality from disorders of the digestive tract. METHODS:We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures. A total of 50,045 adults were enrolled during a 4-year period (2004-2008) and followed annually until December 2012, with a follow-up success rate of 99%. We used Cox proportional hazard regression models to evaluate the association between opium use and outcomes of interest. RESULTS:In all, 8,487 (17%) participants reported opium use, with a mean duration of 12.7 years. During the follow-up period 474 deaths from digestive diseases were reported (387 due to gastrointestinal cancers and 87 due to nonmalignant etiologies). Opium use was associated with an increased risk of death from any digestive disease (adjusted hazard ratio (HR)=1.55, 95% confidence interval (CI)=1.24-1.93). The association was dose dependent, with a HR of 2.21 (1.57-3.31) for the highest quintile of cumulative opium use vs. no use (Ptrend=0.037). The HRs (95% CI) for the associations between opium use and malignant and nonmalignant causes of digestive mortality were 1.38 (1.07-1.76) and 2.60 (1.57-4.31), respectively. Increased risks were seen both for smoking opium and for ingestion of opium. CONCLUSIONS:Long-term opium use, even in low doses, is associated with increased risk of death from both malignant and nonmalignant digestive diseases.

SUBMITTER: Malekzadeh MM

PROVIDER: S-EPMC5752100 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Opium use and risk of mortality from digestive diseases: a prospective cohort study.

Malekzadeh Masoud M MM Khademi Hooman H Pourshams Akram A Etemadi Arash A Poustchi Hossein H Bagheri Mohammad M Khoshnia Masoud M Sohrabpour Amir Ali AA Aliasgari Ali A Jafari Elham E Islami Farhad F Semnani Shahryar S Abnet Christian C CC Pharoah Paul D P PD Brennan Paul P Boffetta Paolo P Dawsey Sanford M SM Malekzadeh Reza R Kamangar Farin F

The American journal of gastroenterology 20131022 11

<h4>Objectives</h4>Opium use, particularly in low doses, is a common practice among adults in northeastern Iran. We aimed to investigate the association between opium use and subsequent mortality from disorders of the digestive tract.<h4>Methods</h4>We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures. A total of 50,045 adults were enrolled during a 4-year period (2004-2008) and follow ...[more]

PMID: 24145676

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Dataset Information

Opium use and risk of mortality from digestive diseases: a prospective cohort study.

Publications

Opium use and risk of mortality from digestive diseases: a prospective cohort study.

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