Ontology highlight
ABSTRACT:
SUBMITTER: Thoendel M
PROVIDER: S-EPMC5752108 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Thoendel Matthew M Jeraldo Patricio R PR Greenwood-Quaintance Kerryl E KE Yao Janet Z JZ Chia Nicholas N Hanssen Arlen D AD Abdel Matthew P MP Patel Robin R
Journal of microbiological methods 20160526
Metagenomic whole genome sequencing for detection of pathogens in clinical samples is an exciting new area for discovery and clinical testing. A major barrier to this approach is the overwhelming ratio of human to pathogen DNA in samples with low pathogen abundance, which is typical of most clinical specimens. Microbial DNA enrichment methods offer the potential to relieve this limitation by improving this ratio. Two commercially available enrichment kits, the NEBNext Microbiome DNA Enrichment K ...[more]